The period from roughly 1999 to 2010. It marks the rampant diseases that affected the war ravaged areas of Africa and Asia in the wake of the Eugenics wars.
As with most such matters the worst of the ravages were poverty driven. The rampant diseases were further fueled by a lack of compassion from the developed countries that had exhausted themselves fighting the eugenic supermen. They were tired, they had emptied the treasury, and they didn't care.
One of the main effects, outside of the death of some 300,000,000 people was the rise of the corporations over national governments.